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In experiments in which dipyridamole was administered while in the feed to mice (as much as 111 months in males and girls) and rats (nearly 128 weeks in males and approximately 142 months in women), there was no evidence of drug-associated carcinogenesis.
Concurrent utilization of aspirin and acetazolamide can cause high serum concentrations of acetazolamide (and toxicity) due to Competitiveness with the renal tubule for secretion.
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